Immunomodulatory action of propolis: IV. Prophylactic activity against Gram-negative infections and adjuvant effect of the water-soluble derivative
Identifieur interne : 001519 ( Main/Exploration ); précédent : 001518; suivant : 001520Immunomodulatory action of propolis: IV. Prophylactic activity against Gram-negative infections and adjuvant effect of the water-soluble derivative
Auteurs : Valentin Dimov [Bulgarie] ; Nina Ivanovska [Bulgarie] ; Vassya Bankova [Bulgarie] ; Simeon Popov [Bulgarie]Source :
- Vaccine [ 0264-410X ] ; 1992.
Abstract
The efficacy of the water-soluble derivative (WSD) of natural propolis (bee glue) was examined for augmentation of host resistance against experimental infections caused by Gram-negative pathogens (Klebsiella pneumoniae, Proteus vulgaris, Escherichia coli, Pseudomonas aeruginosa). The substance was found to induce significant non-specific protection, but did not inhibit the in vitro growth of the same strains. Pretreatment with WSD prior to the standard scheme for tumour necrosis factor (TNF) induction (BCG and two weeks later lipopolysaccharide (LPS)) provoked an interval-dependent reduction in the lytic capacity of serum against L 929 target cells. The replacement of the triggering or priming signal with WSD markedly increased TNF production. In vivo administration of WSD led to a rapid and route-dependent change in the alternative complement pathway haemolysis. The alteration in Clq complement component and total protein synthesis, and also in nitroblue tetrazolium reduction, suggests that macrophage activation makes a major contribution to the capacity of WSD to prevent infections.
Url:
DOI: 10.1016/0264-410X(92)90043-J
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001410
- to stream Istex, to step Curation: 001410
- to stream Istex, to step Checkpoint: 001047
- to stream Main, to step Merge: 001610
- to stream Main, to step Curation: 001519
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Immunomodulatory action of propolis: IV. Prophylactic activity against Gram-negative infections and adjuvant effect of the water-soluble derivative</title><author><name sortKey="Dimov, Valentin" sort="Dimov, Valentin" uniqKey="Dimov V" first="Valentin" last="Dimov">Valentin Dimov</name></author><author><name sortKey="Ivanovska, Nina" sort="Ivanovska, Nina" uniqKey="Ivanovska N" first="Nina" last="Ivanovska">Nina Ivanovska</name></author><author><name sortKey="Bankova, Vassya" sort="Bankova, Vassya" uniqKey="Bankova V" first="Vassya" last="Bankova">Vassya Bankova</name></author><author><name sortKey="Popov, Simeon" sort="Popov, Simeon" uniqKey="Popov S" first="Simeon" last="Popov">Simeon Popov</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:66BDA0391C93AC837D7CFC4D03E1AC1E3808485F</idno><date when="1992" year="1992">1992</date><idno type="doi">10.1016/0264-410X(92)90043-J</idno><idno type="url">https://api.istex.fr/document/66BDA0391C93AC837D7CFC4D03E1AC1E3808485F/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001410</idno><idno type="wicri:Area/Istex/Curation">001410</idno><idno type="wicri:Area/Istex/Checkpoint">001047</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001047</idno><idno type="wicri:doubleKey">0264-410X:1992:Dimov V:immunomodulatory:action:of</idno><idno type="wicri:Area/Main/Merge">001610</idno><idno type="wicri:Area/Main/Curation">001519</idno><idno type="wicri:Area/Main/Exploration">001519</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Immunomodulatory action of propolis: IV. Prophylactic activity against Gram-negative infections and adjuvant effect of the water-soluble derivative</title><author><name sortKey="Dimov, Valentin" sort="Dimov, Valentin" uniqKey="Dimov V" first="Valentin" last="Dimov">Valentin Dimov</name><affiliation wicri:level="1"><country xml:lang="fr">Bulgarie</country><wicri:regionArea>Department of Immunology, Institute of Microbiology, Bulgarian Academy of Sciences, 26 G. Bonchev St, Sofia 1113</wicri:regionArea><placeName><settlement type="city">Sofia</settlement><region nuts="2">Sofia-ville (oblast)</region></placeName></affiliation></author><author><name sortKey="Ivanovska, Nina" sort="Ivanovska, Nina" uniqKey="Ivanovska N" first="Nina" last="Ivanovska">Nina Ivanovska</name><affiliation wicri:level="1"><country xml:lang="fr">Bulgarie</country><wicri:regionArea>Department of Immunology, Institute of Microbiology, Bulgarian Academy of Sciences, 26 G. Bonchev St, Sofia 1113</wicri:regionArea><placeName><settlement type="city">Sofia</settlement><region nuts="2">Sofia-ville (oblast)</region></placeName></affiliation></author><author><name sortKey="Bankova, Vassya" sort="Bankova, Vassya" uniqKey="Bankova V" first="Vassya" last="Bankova">Vassya Bankova</name><affiliation wicri:level="3"><country xml:lang="fr">Bulgarie</country><wicri:regionArea>Institute of Organic Chemistry, Bulgarian Academy of Sciences, Sofia</wicri:regionArea><placeName><settlement type="city">Sofia</settlement><region nuts="2">Sofia-ville (oblast)</region></placeName></affiliation></author><author><name sortKey="Popov, Simeon" sort="Popov, Simeon" uniqKey="Popov S" first="Simeon" last="Popov">Simeon Popov</name><affiliation wicri:level="3"><country xml:lang="fr">Bulgarie</country><wicri:regionArea>Institute of Organic Chemistry, Bulgarian Academy of Sciences, Sofia</wicri:regionArea><placeName><settlement type="city">Sofia</settlement><region nuts="2">Sofia-ville (oblast)</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Vaccine</title><title level="j" type="abbrev">JVAC</title><idno type="ISSN">0264-410X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1992">1992</date><biblScope unit="volume">10</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="817">817</biblScope><biblScope unit="page" to="823">823</biblScope></imprint><idno type="ISSN">0264-410X</idno></series><idno type="istex">66BDA0391C93AC837D7CFC4D03E1AC1E3808485F</idno><idno type="DOI">10.1016/0264-410X(92)90043-J</idno><idno type="PII">0264-410X(92)90043-J</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0264-410X</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The efficacy of the water-soluble derivative (WSD) of natural propolis (bee glue) was examined for augmentation of host resistance against experimental infections caused by Gram-negative pathogens (Klebsiella pneumoniae, Proteus vulgaris, Escherichia coli, Pseudomonas aeruginosa). The substance was found to induce significant non-specific protection, but did not inhibit the in vitro growth of the same strains. Pretreatment with WSD prior to the standard scheme for tumour necrosis factor (TNF) induction (BCG and two weeks later lipopolysaccharide (LPS)) provoked an interval-dependent reduction in the lytic capacity of serum against L 929 target cells. The replacement of the triggering or priming signal with WSD markedly increased TNF production. In vivo administration of WSD led to a rapid and route-dependent change in the alternative complement pathway haemolysis. The alteration in Clq complement component and total protein synthesis, and also in nitroblue tetrazolium reduction, suggests that macrophage activation makes a major contribution to the capacity of WSD to prevent infections.</div></front></TEI><affiliations><list><country><li>Bulgarie</li></country><region><li>Sofia-ville (oblast)</li></region><settlement><li>Sofia</li></settlement></list><tree><country name="Bulgarie"><region name="Sofia-ville (oblast)"><name sortKey="Dimov, Valentin" sort="Dimov, Valentin" uniqKey="Dimov V" first="Valentin" last="Dimov">Valentin Dimov</name></region><name sortKey="Bankova, Vassya" sort="Bankova, Vassya" uniqKey="Bankova V" first="Vassya" last="Bankova">Vassya Bankova</name><name sortKey="Ivanovska, Nina" sort="Ivanovska, Nina" uniqKey="Ivanovska N" first="Nina" last="Ivanovska">Nina Ivanovska</name><name sortKey="Popov, Simeon" sort="Popov, Simeon" uniqKey="Popov S" first="Simeon" last="Popov">Simeon Popov</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Eau/explor/LotaV3/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001519 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001519 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Eau
|area= LotaV3
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:66BDA0391C93AC837D7CFC4D03E1AC1E3808485F
|texte= Immunomodulatory action of propolis: IV. Prophylactic activity against Gram-negative infections and adjuvant effect of the water-soluble derivative
}}
| This area was generated with Dilib version V0.6.39. |  |